ABSTRACT
Objectives: The aim of the study was to investigate the antidepressant effect of Phyllanthus amarus ethanolic extract in Wistar albino rats. Methods: The ethanolic extract of leaves of Phyllanthus amarus [PAEE] at a dose of 100mg/kg/body weight was administered orally for ten days. On tenth day, after one hour, the animals were taken for forced swimming test, to assess the level of depression. Results: The results indicate PAEE has significant antidepressant activity Conclusions: The antidepressant activity of Phyllanthus amarus can be due to its effect on brain neurotransmitters or due to antioxidant property.
ABSTRACT
Objectives: The aim of the study was to test the effect of whole body electron beam radiation on anxiety statein Swiss albino mice. Methods: Mice were irradiated with three different doses (2Gy,4Gy,6Gy)of electron beam radiations.After 24hours of radiation exposure animals were taken for testing level of anxiety using elevated plus maze and light dark arena apparatus. Results: Whole body electron beam irradiation at doses of 2, 4 and 6Gy lead to significant (p<0.001) anxiogenic activity in irradiated mice. Conclusions: Electron beam radiation has the potential to cause anxiety.
ABSTRACT
Objectives: The aim of the study was to investigate the anticataleptic effect of Phyllanthus amarus ethanolic extract in Swiss albino mice. Methods: The ethanolic extract of leaves of Phyllanthus amarus [PAEE] at a dose of 100mg/kg/body weight was administered orally for ten days. On tenth day, one hour later Haloperidol [1 mg/ kg IP] was administered to induce catalepsy. Results: The results indicate that induction of catalepsy by Haloperidol in Swiss albino mice was significantly prevented by PAEE. Conclusions: The anticataleptic activity of Phyllanthus amarus can be due to its effect on brain neurotransmitters or due to antioxidant property.
ABSTRACT
Objectives: The aim of this study was to investigate anticonvulsant effect of Phyllanthus amarus on maximal electroshock-induced seizures (MES) and pentylenetetrazole (PTZ) induced seizures. Methods: The aqueous and ethanolic extracts of the leaves and stems of P. amarus (70 mg/kg, p.o) were studied for their anticonvulsant effect on MES and PTZ induced seizures in Swiss albino rats. The latency of tonic convulsions and the number of animals protected from tonic convulsions were noted. Results: The aqueous and ethanolic extracts of the leaves and stems of P. amarus (70 mg/kg, p.o) significantly (p<0.001) abolished the hind limb extension induced by MES. The same dose also significantly (p<0.001) protected the animals from PTZ induced tonic convulsions. Conclusions: The data suggests that the aqueous and ethanolic extracts of P. amarus may produce its anticonvulsant effects via non-specific mechanisms since it abolished the hind limb extension induced by MES as well as delayed the latency of seizures produced by PTZ.
ABSTRACT
The seeds of C. sativum are used as a traditional drug for the treatment of diabetes. The antioxidant and free-radical-scavenging property of seeds in vitro was studied and also investigated whether the administration of seeds curtails oxidative stress in the kidney of streptozotocin-induced diabetic rats. Incorporation of seed powder in the diet led to marked lowering of blood glucose and a rise in the levels of insulin in diabetic rats. A parallel beneficial effect was observed on oxidant –antioxidant balance in the kidney. Addition of coriander seed powder not only inhibited the process of peroxidative damage but also significantly reactivated the antioxidant enzymes and antioxidant levels in diabetic rats. The total polyphenolic content of the seeds was found to be 12.2 gallic acid equivalents (GAE)/g while total flavanoid content was found to be 12.6 quercetin equivalents/g. The seeds also showed scavenging activity against superoxides and hydroxyl radicals in a concentration -dependent manner. Maximum free radical-scavenging action and free radical reducing power of coriander seed extract was observed at a concentration of 50 g GAE. Islet histology structures showed degeneration of pancreatic islets in diabetic rats which was also reduced in diabetic rats treated with seed powder. These results show that C. sativum seeds not only possess antihyperglycemic properties but antioxidative properties also. Increased dietary intake of coriander seeds decrease the oxidative burden in diabetes mellitus.